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Activation-induced Degradation of FLIP(L) Is Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages
Cellular FLIP (Flice-like inhibitory protein) is critical for the protection against death receptor-mediated cell apoptosis. In macrophages, FLIP long (FLIP(L)) and FLIP short (FLIP(S)) mRNA was induced by tumor necrosis factor (TNF) α, mediated through NF-κB. However, we observed TNFα reduced the p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2682900/ https://ncbi.nlm.nih.gov/pubmed/19339247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807918200 |
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