Cell Surface Biliverdin Reductase Mediates Biliverdin-induced Anti-inflammatory Effects via Phosphatidylinositol 3-Kinase and Akt

Biliverdin reductase A (BVR) catalyzes the reduction of biliverdin (BV) to bilirubin (BR) in all cells. Others and we have shown that biliverdin is a potent anti-inflammatory molecule, however, the mechanism by which BV exerts its protective effects is unclear. We describe and elucidate a novel find...

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Detalhes bibliográficos
Main Authors: Wegiel, Barbara, Baty, Catherine J., Gallo, David, Csizmadia, Eva, Scott, Jeffrey R., Akhavan, Ardavan, Chin, Beek Y., Kaczmarek, Elzbieta, Alam, Jawed, Bach, Fritz H., Zuckerbraun, Brian S., Otterbein, Leo E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755861/
https://ncbi.nlm.nih.gov/pubmed/19509285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027433
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