Deletion of Biliverdin Reductase A in myeloid cells promotes chemokine expression and chemotaxis in part via a complement C5a-C5aR1 pathway

Biliverdin reductase A (BVR-A) is a pleotropic enzyme converting biliverdin (BV) to bilirubin (BR), and a signaling molecule that has cytoprotective and immunomodulatory effects. We recently showed that BV inhibits the expression of complement activation fragment 5a receptor (C5aR1) in 264.7 RAW mac...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Bisht, Kavita, Canesin, Giacomo, Cheytan, Tasneem, Li, Mailin, Nemeth, Zsuzsanna, Csizmadia, Eva, Woodruff, Trent M., Stec, David E., Bulmer, Andrew C., Otterbein, Leo E., Wegiel, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504595/
https://ncbi.nlm.nih.gov/pubmed/30952817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701443
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