Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice

OBJECTIVE: The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of β-cell mass. RESEARCH DESIGN AND METHODS: We analyzed the capacity of β-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after short-term treatment with the gluca...

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Bibliographic Details
Main Authors: Tschen, Shuen-Ing, Dhawan, Sangeeta, Gurlo, Tatyana, Bhushan, Anil
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682690/
https://ncbi.nlm.nih.gov/pubmed/19228811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1651
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