Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor

Human herpesvirus 8 encodes a viral version of interleukin-6 (vIL-6) which shows 25% sequence homology with human IL-6. In contrast to human IL-6, which first binds to the IL-6 receptor (IL-6R) and only subsequently associates with the signal transducing receptor subunit gp130, vIL-6 has been shown...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Adam, Nina, Rabe, Björn, Suthaus, Jan, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2009
נושאים:
Cellular Response to Infection
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682076/
https://ncbi.nlm.nih.gov/pubmed/19264784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01601-08
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