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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling control...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163962/ https://ncbi.nlm.nih.gov/pubmed/21881215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57158 |
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