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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling control...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163962/ https://ncbi.nlm.nih.gov/pubmed/21881215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57158 |
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