Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver

Heterozygous HNF1A mutations cause pancreatic-islet β-cell dysfunction and monogenic diabetes (MODY3). Hnf1α is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific chan...

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Bibliografiset tiedot
Päätekijät: Servitja, Joan-Marc, Pignatelli, Miguel, Maestro, Miguel Ángel, Cardalda, Carina, Boj, Sylvia F., Lozano, Juanjo, Blanco, Enrique, Lafuente, Amàlia, McCarthy, Mark I., Sumoy, Lauro, Guigó, Roderic, Ferrer, Jorge
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2009
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682018/
https://ncbi.nlm.nih.gov/pubmed/19289501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01389-08
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