Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver

Heterozygous HNF1A mutations cause pancreatic-islet β-cell dysfunction and monogenic diabetes (MODY3). Hnf1α is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific chan...

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Main Authors: Servitja, Joan-Marc, Pignatelli, Miguel, Maestro, Miguel Ángel, Cardalda, Carina, Boj, Sylvia F., Lozano, Juanjo, Blanco, Enrique, Lafuente, Amàlia, McCarthy, Mark I., Sumoy, Lauro, Guigó, Roderic, Ferrer, Jorge
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682018/
https://ncbi.nlm.nih.gov/pubmed/19289501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01389-08
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