Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver

Heterozygous HNF1A mutations cause pancreatic-islet β-cell dysfunction and monogenic diabetes (MODY3). Hnf1α is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific chan...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Servitja, Joan-Marc, Pignatelli, Miguel, Maestro, Miguel Ángel, Cardalda, Carina, Boj, Sylvia F., Lozano, Juanjo, Blanco, Enrique, Lafuente, Amàlia, McCarthy, Mark I., Sumoy, Lauro, Guigó, Roderic, Ferrer, Jorge
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682018/
https://ncbi.nlm.nih.gov/pubmed/19289501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01389-08
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