Induction of Alpha/Beta Interferon by Myxoma Virus Is Selectively Abrogated When Primary Mouse Embryo Fibroblasts Become Immortalized

Mouse embryo fibroblasts (MEFs) are a widely used cell culture system in life sciences, including virology. Here, we show that although primary MEFs are nonpermissive to myxoma virus replication, the corresponding immortalized MEFs support a highly productive myxoma virus infection. We further demon...

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Bibliographic Details
Main Authors:	Wang, Fuan, Barrett, John W., Ma, Yiyue, Dekaban, Gregory A., McFadden, Grant
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2009
Subjects:	Cellular Response to Infection
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2681981/ https://ncbi.nlm.nih.gov/pubmed/19297474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02587-08
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Induction of Alpha/Beta Interferon by Myxoma Virus Is Selectively Abrogated When Primary Mouse Embryo Fibroblasts Become Immortalized

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