In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

Simocyclinone D8 (SD8) exhibits antibiotic activity against gram-positive bacteria but not against gram-negative bacteria. The molecular basis of the cytotoxicity of SD8 is not fully understood, although SD8 has been shown to inhibit the supercoiling activity of Escherichia coli gyrase. To understan...

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Detalhes bibliográficos
Main Authors: Oppegard, Lisa M., Hamann, Bree L., Streck, Kathryn R., Ellis, Keith C., Fiedler, Hans-Peter, Khodursky, Arkady B., Hiasa, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681514/
https://ncbi.nlm.nih.gov/pubmed/19273673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01440-08
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