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Simocyclinone D8, an Inhibitor of DNA Gyrase with a Novel Mode of Action
We have characterized the interaction of a new class of antibiotics, simocyclinones, with bacterial DNA gyrase. Even though their structures include an aminocoumarin moiety, a key feature of novobiocin, coumermycin A(1), and clorobiocin, which also target gyrase, simocyclinones behave strikingly dif...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549283/ https://ncbi.nlm.nih.gov/pubmed/15728908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1093-1100.2005 |
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