Structure-Activity Relationships of Aminocoumarin-Type Gyrase and Topoisomerase IV Inhibitors Obtained by Combinatorial Biosynthesis

Novobiocin and clorobiocin are gyrase inhibitors produced by Streptomyces strains. Structurally, the two compounds differ only by substitution at two positions: CH(3) versus Cl at position 8′ of the aminocoumarin ring and carbamoyl versus 5-methyl-pyrrol-2-carbonyl (MePC) at the 3"-OH of novios...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Flatman, Ruth H., Eustaquio, Alessandra, Li, Shu-Ming, Heide, Lutz, Maxwell, Anthony
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2006
Aiheet:
Chemistry; Biosynthesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426943/
https://ncbi.nlm.nih.gov/pubmed/16569821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1136-1142.2006
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