Simocyclinone D8, an Inhibitor of DNA Gyrase with a Novel Mode of Action

We have characterized the interaction of a new class of antibiotics, simocyclinones, with bacterial DNA gyrase. Even though their structures include an aminocoumarin moiety, a key feature of novobiocin, coumermycin A(1), and clorobiocin, which also target gyrase, simocyclinones behave strikingly dif...

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Bibliografiset tiedot
Päätekijät: Flatman, Ruth H., Howells, Alison J., Heide, Lutz, Fiedler, Hans-Peter, Maxwell, Anthony
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2005
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC549283/
https://ncbi.nlm.nih.gov/pubmed/15728908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1093-1100.2005
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