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Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10

The purpose of this work was to identify human UDP-glucuronosyltransferases (UGTs) capable of glucuronidating dopamine. Using a sensitive liquid chromatography-tandem mass spectrometry method, we screened all 19 known human UGTs and found that only one enzyme, UGT1A10, catalyzed dopamine glucuronida...

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Bibliografski detalji
Glavni autori: Itäaho, Katriina, Court, Michael H., Uutela, Päivi, Kostiainen, Risto, Radominska-Pandya, Anna, Finel, Moshe
Format: Artigo
Jezik:Inglês
Izdano: American Society for Pharmacology and Experimental Therapeutics 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680538/
https://ncbi.nlm.nih.gov/pubmed/19116261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.025692
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