Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10

The purpose of this work was to identify human UDP-glucuronosyltransferases (UGTs) capable of glucuronidating dopamine. Using a sensitive liquid chromatography-tandem mass spectrometry method, we screened all 19 known human UGTs and found that only one enzyme, UGT1A10, catalyzed dopamine glucuronida...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Itäaho, Katriina, Court, Michael H., Uutela, Päivi, Kostiainen, Risto, Radominska-Pandya, Anna, Finel, Moshe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Pharmacology and Experimental Therapeutics 2009
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680538/
https://ncbi.nlm.nih.gov/pubmed/19116261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.025692
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