Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10

[Image: see text] Intestinal and hepatic glucuronidation by the UDP-glucuronosyltransferases (UGTs) greatly affect the bioavailability of phenolic compounds. UGT1A10 catalyzes glucuronidation reactions in the intestine, but not in the liver. Here, our aim was to develop selective, fluorescent substr...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Juvonen, Risto O., Rauhamäki, Sanna, Kortet, Sami, Niinivehmas, Sanna, Troberg, Johanna, Petsalo, Aleksanteri, Huuskonen, Juhani, Raunio, Hannu, Finel, Moshe, Pentikäinen, Olli T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150735/
https://ncbi.nlm.nih.gov/pubmed/29421866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00871
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