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Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
[Image: see text] Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. Currently used CYP substrates, such as 7-ethoxycoumarin and 7-e...
Tallennettuna:
| Julkaisussa: | ACS Omega |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Chemical Society
2021
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| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8153946/ https://ncbi.nlm.nih.gov/pubmed/34056284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c00123 |
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