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Blocking Estrogen Signaling After the Hormone: Pyrimidine-Core Inhibitors of Estrogen Receptor-Coactivator Binding

As an alternative approach to blocking estrogen action, we have developed small molecules that directly disrupt the key estrogen receptor (ER)/coactivator interaction necessary for gene activation. The more direct, protein-protein nature of this disruption might be effective even in hormone-refracto...

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Autors principals: Parent, Alexander A., Gunther, Jillian R., Katzenellenbogen, John A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680390/
https://ncbi.nlm.nih.gov/pubmed/18785725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800698b
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