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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
Integrins are the major adhesion receptors of leukocytes and platelets. β(1) and β(2) integrin function on leukocytes is crucial for a successful immune response and the platelet integrin α(IIb)β(3) initiates the process of blood clotting through binding fibrinogen1-3. Integrins on circulating cells...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680140/ https://ncbi.nlm.nih.gov/pubmed/19234463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1931 |
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