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Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs

Conjugation of drugs with antibodies to surface endothelial antigens is a potential strategy for drug delivery to endothelium. We studied antibodies to platelet-endothelial adhesion molecule 1 (PECAM-1, a stably expressed endothelial antigen) as carriers for vascular immunotargeting. Although (125)I...

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Detalhes bibliográficos
Main Authors: Muzykantov, Vladimir R., Christofidou-Solomidou, Melpo, Balyasnikova, Irina, Harshaw, David W., Schultz, Linda, Fisher, Aron B., Albelda, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26792/
https://ncbi.nlm.nih.gov/pubmed/10051650
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