Vascular Immunotargeting of Glucose Oxidase to the Endothelial Antigens Induces Distinct Forms of Oxidant Acute Lung Injury : Targeting to Thrombomodulin, But Not to PECAM-1, Causes Pulmonary Thrombosis and Neutrophil Transmigration

Oxidative endothelial stress, leukocyte transmigration, and pulmonary thrombosis are important pathological factors in acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Vascular immunotargeting of the H(2)O(2)-generating enzyme glucose oxidase (GOX) to the pulmonary endothelium cause...

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Detalhes bibliográficos
Main Authors: Christofidou-Solomidou, Melpo, Kennel, Stephen, Scherpereel, Arnaud, Wiewrodt, Rainer, Solomides, Charalambos C., Pietra, Giuseppe G., Murciano, Juan-Carlos, Shah, Sayed A., Ischiropoulos, Harry, Albelda, Steven M., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Animal Model
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867171/
https://ncbi.nlm.nih.gov/pubmed/11891211
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