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Structural basis for cAMP-mediated allosteric control of the catabolite activator protein

The cAMP-mediated allosteric transition in the catabolite activator protein (CAP; also known as the cAMP receptor protein, CRP) is a textbook example of modulation of DNA-binding activity by small-molecule binding. Here we report the structure of CAP in the absence of cAMP, which, together with stru...

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Autors principals: Popovych, Nataliya, Tzeng, Shiou-Ru, Tonelli, Marco, Ebright, Richard H., Kalodimos, Charalampos G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678429/
https://ncbi.nlm.nih.gov/pubmed/19359484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900595106
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