LIP5 Interacts with Aquaporin 2 and Facilitates Its Lysosomal Degradation

Vasopressin binding to the V2 receptor in renal principal cells leads to activation of protein kinase A, phosphorylation of aquaporin 2 (AQP2) at Ser256, and the translocation of AQP2 to the apical membrane, resulting in concentration of the urine. In contrast, phorbol ester–induced activation of pr...

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Autors principals: van Balkom, Bas W.M., Boone, Michelle, Hendriks, Giel, Kamsteeg, Erik-Jan, Robben, Joris H., Stronks, H. Christiaan, van der Voorde, Anne, van Herp, Francois, van der Sluijs, Peter, Deen, Peter M.T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2009
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678037/
https://ncbi.nlm.nih.gov/pubmed/19357255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008060648
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