Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

The interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation. This interaction is part of a process that controls AQP2 apical membrane abundance in a vas...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Roche, Jennifer Virginia, Survery, Sabeen, Kreida, Stefan, Nesverova, Veronika, Ampah-Korsah, Henry, Gourdon, Maria, Deen, Peter M. T., Törnroth-Horsefield, Susanna
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582854/
https://ncbi.nlm.nih.gov/pubmed/28710278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788364
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