Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus

Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal collecting ducts, resulting in water reabsorption from urine. Mutations in AQP2 cause autosomal nephrogenic diabetes insipidus (NDI), a disease...

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Hauptverfasser: Kamsteeg, Erik-Jan, Bichet, Daniel G., Konings, Irene B.M., Nivet, Hubert, Lonergan, Michelle, Arthus, Marie-Françoise, van Os, Carel H., Deen, Peter M.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173618/
https://ncbi.nlm.nih.gov/pubmed/14662748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309017
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