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TREX2 Exonuclease Defective Cells Exhibit Double-Strand Breaks and Chromosomal Fragments but Not Robertsonian Translocations
TREX2 is a 3′→5′ exonuclease that binds to DNA and removes 3′ mismatched nucleotides. By an in vitro structure function analysis, we found a single amino acid change (H188A) completely ablates exonuclease activity and impairs DNA binding by about 60% while another change (R167A) impairs DNA binding...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677549/ https://ncbi.nlm.nih.gov/pubmed/19094998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2008.11.012 |
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