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TREX2 Exonuclease Defective Cells Exhibit Double-Strand Breaks and Chromosomal Fragments but Not Robertsonian Translocations

TREX2 is a 3′→5′ exonuclease that binds to DNA and removes 3′ mismatched nucleotides. By an in vitro structure function analysis, we found a single amino acid change (H188A) completely ablates exonuclease activity and impairs DNA binding by about 60% while another change (R167A) impairs DNA binding...

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Detalhes bibliográficos
Main Authors: Dumitrache, Lavinia C., Hu, Lingchuan, Hasty, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677549/
https://ncbi.nlm.nih.gov/pubmed/19094998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2008.11.012
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