Trex2 Enables Spontaneous Sister Chromatid Exchanges Without Facilitating DNA Double-Strand Break Repair

Trex2 is a 3′ → 5′ exonuclease that removes 3′-mismatched sequences in a biochemical assay; however, its biological function remains unclear. To address biology we previously generated trex2(null) mouse embryonic stem (ES) cells and expressed in these cells wild-type human TREX2 cDNA (Trex2(hTX2)) o...

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Autores principales: Dumitrache, Lavinia C., Hu, Lingchuan, Son, Mi Young, Li, Han, Wesevich, Austin, Scully, Ralph, Stark, Jeremy, Hasty, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2011
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Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176084/
https://ncbi.nlm.nih.gov/pubmed/21546543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.129833
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