The Role of NADPH Oxidase in Chronic Intermittent Hypoxia-Induced Pulmonary Hypertension in Mice

Obstructive sleep apnea, characterized by intermittent periods of hypoxemia, is an independent risk factor for the development of pulmonary hypertension. However, the exact mechanisms of this disorder remain to be defined. Enhanced NADPH oxidase expression and superoxide (O(2)(−)·) generation in the...

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Autori principali: Nisbet, Rachel E., Graves, Anitra S., Kleinhenz, Dean J., Rupnow, Heidi L., Reed, Alana L., Fan, Tai-Hwang M., Mitchell, Patrick O., Sutliff, Roy L., Hart, C. Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677439/
https://ncbi.nlm.nih.gov/pubmed/18952568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0145OC
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