Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain

Niemann-Pick Type C (NPC) disease is a devastating developmental disorder with progressive and fatal neurodegeneration. Previous work has shown that a single injection of the neurosteroid allopregnanolone at postnatal day 7 significantly prolonged lifespan of Npc1-/- mice. However, the cellular/mole...

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Hauptverfasser: Liao, Guanghong, Cheung, Simon, Galeano, James, Ji, Angela X., Qin, Qingyu, Bi, Xiaoning
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677133/
https://ncbi.nlm.nih.gov/pubmed/19328188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.03.027
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