Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the pathogenesis of numerous neurodegenerative diseases...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cermak, Stjepko, Kosicek, Marko, Mladenovic-Djordjevic, Aleksandra, Smiljanic, Kosara, Kanazir, Selma, Hecimovic, Silva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
https://ncbi.nlm.nih.gov/pubmed/27902765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167428
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