Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the pathogenesis of numerous neurodegenerative diseases...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Cermak, Stjepko, Kosicek, Marko, Mladenovic-Djordjevic, Aleksandra, Smiljanic, Kosara, Kanazir, Selma, Hecimovic, Silva
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
https://ncbi.nlm.nih.gov/pubmed/27902765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167428
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items