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Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

It has been suggested that cholesterol may modulate amyloid-β (Aβ) formation, a causative factor of Alzheimer's disease (AD), by regulating distribution of the three key proteins in the pathogenesis of AD (β-amyloid precursor protein (APP), β-secretase (BACE1) and/or presenilin 1 (PS1)) within...

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Detalhes bibliográficos
Main Authors: Kosicek, Marko, Malnar, Martina, Goate, Alison, Hecimovic, Silva
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853640/
https://ncbi.nlm.nih.gov/pubmed/20138836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.02.007
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