Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the pathogenesis of numerous neurodegenerative diseases...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Cermak, Stjepko, Kosicek, Marko, Mladenovic-Djordjevic, Aleksandra, Smiljanic, Kosara, Kanazir, Selma, Hecimovic, Silva
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
https://ncbi.nlm.nih.gov/pubmed/27902765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167428
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