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The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity
WTX encodes a tumor suppressor gene inactivated in Wilms tumor and recently implicated in WNT signaling through enhancement of cytoplasmic β-catenin (CTNNB1) degradation. Here, we report that WTX translocates to the nucleus, a property that is modified by an endogenous splicing variant and is modula...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677091/ https://ncbi.nlm.nih.gov/pubmed/19416806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811349106 |
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