The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification

WTX is an X-linked tumor suppressor targeted by somatic mutations in Wilms tumor, a pediatric kidney cancer, and by germline inactivation in osteopathia striata with cranial sclerosis, a bone overgrowth syndrome. Here, we show that Wtx deletion in mice causes neonatal lethality, somatic overgrowth,...

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Main Authors: Moisan, Annie, Rivera, Miguel N., Lotinun, Sutada, Akhavanfard, Sara, Coffman, Erik J., Cook, Edward B., Stoykova, Svetlana, Mukherjee, Siddhartha, Schoonmaker, Jesse A., Burger, Alexa, Kim, Woo Jae, Kronenberg, Henry M., Baron, Roland, Haber, Daniel A., Bardeesy, Nabeel
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052985/
https://ncbi.nlm.nih.gov/pubmed/21571217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.03.013
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