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Lessons from Polyoma Middle T Antigen on Signaling and Transformation: A DNA Tumor Virus Contribution to the War on Cancer

Middle T antigen (MT) is the principal oncogene of murine polyomavirus. Its study has led to the discovery of the roles tyrosine kinase and phosphoinositide 3-kinase (PI3K) signaling in mammalian growth control and transformation. MT is necessary for viral transformation in tissue culture cells and...

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Библиографические подробности
Главные авторы: Schaffhausen, Brian S., Roberts, Thomas M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676342/
https://ncbi.nlm.nih.gov/pubmed/19022468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.09.042
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