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Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity

The calpain family of cysteine proteases has a well-established causal role in neuronal cell death following acute brain injury. However, the relative contribution of calpain isoforms to the various forms of injury has not been determined as available calpain inhibitors are not isoform-specific. In...

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Autores principales: Bevers, Matthew B., Lawrence, Eric, Maronski, Margaret, Starr, Neasa, Amesquita, Michael, Neumar, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676331/
https://ncbi.nlm.nih.gov/pubmed/19141074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05860.x
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