RNAi targeting μ-calpain increases neuron survival and preserves hippocampal function after global brain ischemia

The calpain family of cysteine proteases has a well-established causal role in neuronal cell death following acute brain injury. However, the relative contribution of calpain isoforms has not been determined in in vivo models. Identification of the calpain isoform responsible for neuronal injury is...

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Main Authors: Bevers, Matthew B., Ingleton, Lori P., Che, Dongfang, Li, Luchuan, Da, Tong, Kopil, Catherine M., Cohen, Akiva S., Neumar, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885584/
https://ncbi.nlm.nih.gov/pubmed/20298691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2010.03.007
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