Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of striatal-enriched protein tyrosine phosphatase (STEP) in this critical process. STEP(61) is an alternatively spliced member...

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Main Authors: Xu, Jian, Kurup, Pradeep, Zhang, Yongfang, Goebel-Goody, Susan M., Wu, Peter H., Hawasli, Ammar H., Baum, Matthew L., Bibb, James A., Lombroso, Paul J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737362/
https://ncbi.nlm.nih.gov/pubmed/19625523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2212-09.2009
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