Loading...

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of striatal-enriched protein tyrosine phosphatase (STEP) in this critical process. STEP(61) is an alternatively spliced member...

Full description

Saved in:
Bibliographic Details
Main Authors: Xu, Jian, Kurup, Pradeep, Zhang, Yongfang, Goebel-Goody, Susan M., Wu, Peter H., Hawasli, Ammar H., Baum, Matthew L., Bibb, James A., Lombroso, Paul J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737362/
https://ncbi.nlm.nih.gov/pubmed/19625523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2212-09.2009
Tags: Add Tag
No Tags, Be the first to tag this record!