NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

N-methyl- -aspartate receptors (NMDAR) overactivation is linked to neurodegeneration. The current prevailing theory suggests that synaptic and extrasynaptic NMDAR (syn- and ex-NMDAR) impose counteracting effects on cell fate, and neuronal cell death is mainly mediated by the activation of ex-NMDAR....

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Autori principali: Zhou, X, Hollern, D, Liao, J, Andrechek, E, Wang, H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615746/
https://ncbi.nlm.nih.gov/pubmed/23538441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.82
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