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NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
N-methyl- -aspartate receptors (NMDAR) overactivation is linked to neurodegeneration. The current prevailing theory suggests that synaptic and extrasynaptic NMDAR (syn- and ex-NMDAR) impose counteracting effects on cell fate, and neuronal cell death is mainly mediated by the activation of ex-NMDAR....
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615746/ https://ncbi.nlm.nih.gov/pubmed/23538441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.82 |
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