Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2 Deficient Mouse Model of Congenital Generalized Lipodystrophy

Mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) cause congenital generalized lipodystrophy. To understand the molecular mechanisms underlying the metabolic complications associated with AGPAT2 deficiency, Agpat2 null mice were generated. Agpat2(−/−) mice develop severe lipodystr...

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Main Authors: Cortés, Víctor A., Curtis, David E., Sukumaran, Suja, Shao, Xinli, Parameswara, Vinay, Rashid, Shirya, Smith, Amy R., Ren, Jimin, Esser, Victoria, Hammer, Robert E., Agarwal, Anil K., Horton, Jay D., Garg, Abhimanyu
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673980/
https://ncbi.nlm.nih.gov/pubmed/19187773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.01.002
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