Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2 Deficient Mouse Model of Congenital Generalized Lipodystrophy

Mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) cause congenital generalized lipodystrophy. To understand the molecular mechanisms underlying the metabolic complications associated with AGPAT2 deficiency, Agpat2 null mice were generated. Agpat2(−/−) mice develop severe lipodystr...

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Detalhes bibliográficos
Main Authors: Cortés, Víctor A., Curtis, David E., Sukumaran, Suja, Shao, Xinli, Parameswara, Vinay, Rashid, Shirya, Smith, Amy R., Ren, Jimin, Esser, Victoria, Hammer, Robert E., Agarwal, Anil K., Horton, Jay D., Garg, Abhimanyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673980/
https://ncbi.nlm.nih.gov/pubmed/19187773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.01.002
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