Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State

Multinucleated giant cells, formed by fusion of macrophages, are a hallmark of granulomatous inflammation. With a genetic approach, we show that signaling through the adaptor protein DAP12 (DNAX activating protein of 12 kD), its associated receptor triggering receptor expressed by myeloid cells 2 (T...

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Autori principali: Helming, Laura, Tomasello, Elena, Kyriakides, Themis R., Martinez, Fernando O., Takai, Toshiyuki, Gordon, Siamon, Vivier, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673960/
https://ncbi.nlm.nih.gov/pubmed/18957693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.1159665
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