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Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State
Multinucleated giant cells, formed by fusion of macrophages, are a hallmark of granulomatous inflammation. With a genetic approach, we show that signaling through the adaptor protein DAP12 (DNAX activating protein of 12 kD), its associated receptor triggering receptor expressed by myeloid cells 2 (T...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673960/ https://ncbi.nlm.nih.gov/pubmed/18957693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.1159665 |
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