Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA methylation with DNA methylation inhibitors has been shown to result in cancer cell differentiation or apoptosis and repres...

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Autors principals: Liu, Zhongfa, Liu, Shujun, Xie, Zhiliang, Pavlovicz, Ryan E., Wu, Jiejun, Chen, Ping, Aimiuwu, Josephine, Pang, Jiuxia, Bhasin, Deepak, Neviani, Paolo, Fuchs, James R., Plass, Christoph, Li, Pui-Kai, Li, Chenglong, Huang, Tim H.-M., Wu, Lai-Chu, Rush, Laura, Wang, Hongyan, Perrotti, Danilo, Marcucci, Guido, Chan, Kenneth K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Chemotherapy, Antibiotics, and Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672871/
https://ncbi.nlm.nih.gov/pubmed/19201992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.147934
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