Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer’s disease and mouse models. Immunotherapy to remove amyloid beta is a promising the...

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Hlavní autoři: Spires-Jones, Tara L, Mielke, Matthew, Rozkalne, Anete, Meyer-Luehmann, Melanie, de Calignon, Alix, Bacskai, Brian J, Schenk, Dale, Hyman, Bradley T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672591/
https://ncbi.nlm.nih.gov/pubmed/19028582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.10.011
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