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Identifying critical residues in protein folding: Insights from ϕ-value and P(fold) analysis
We apply a simulational proxy of the ϕ-value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice Gō polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Institute of Physics
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671670/ https://ncbi.nlm.nih.gov/pubmed/19044896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.2973624 |
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