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Identifying critical residues in protein folding: Insights from ϕ-value and P(fold) analysis

We apply a simulational proxy of the ϕ-value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice Gō polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one...

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Hlavní autoři: Faísca, P. F. N., Travasso, R. D. M., Ball, R. C., Shakhnovich, E. I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Institute of Physics 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671670/
https://ncbi.nlm.nih.gov/pubmed/19044896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.2973624
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