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Φ values in protein-folding kinetics have energetic and structural components

Φ values are experimental measures of how the kinetics of protein folding is changed by single-site mutations. Φ values measure energetic quantities, but they are often interpreted in terms of the structures of the transition-state ensemble. Here, we describe a simple analytical model of the folding...

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Autors principals: Merlo, Claudia, Dill, Ken A., Weikl, Thomas R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177393/
https://ncbi.nlm.nih.gov/pubmed/16009941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504171102
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