Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

Hyperhomocysteinemia and β-amyloid (Aβ) overproduction are critical etiological and pathological factors in Alzheimer disease, respectively; however, the intrinsic link between them is still missing. Here, we found that Aβ levels increased and amyloid precursor protein (APP) levels simultaneously de...

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Main Authors: Zhang, Chang-E, Wei, Wei, Liu, Ying-Hua, Peng, Jun-Hua, Tian, Qing, Liu, Gong-Ping, Zhang, Yao, Wang, Jian-Zhi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2009
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671378/
https://ncbi.nlm.nih.gov/pubmed/19264913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.081036
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